Clinical Handbook of Schizophrenia by Kim T. Mueser PhD, Dilip V. Jeste MD
By Kim T. Mueser PhD, Dilip V. Jeste MD
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The images were much clearer than those with CAT, and allowed differentiation of the white and gray matter. MRI studies of schizophrenia consistently reported ventricular enlargement, decreased cortical volume, and disproportionate volume loss in the temporal lobe. Neuroimaging studies of schizophrenia are limited by their use of convenience clinical samples that are generally small and a lack of specificity of findings (compared to those of other serious mental illnesses). Despite these limitations, the MRI techniques brought an understanding of the neuroanatomical substrates of schizophrenia in sight.
KEY POINTS • The history of schizophrenia as a psychiatric disorder represents the history of modern neuropsychiatry, neuropsychopharmacology, and neuroscience. ” Émil Kraepelin (1856–1927) integrated the contemporary concept of dementia praecox on the basis of the characteristic course and outcome of a cluster of symptoms and signs, but also stated that the disorder had a specific neuroanatomical pathology and etiology. The Swiss psychiatrist, Eugen Bleuler, coined the term schizophrenia in 1911.
Most consistently this has been shown for African Caribbean migrants to the United Kingdom. A number of studies using different methodologies and different sets of diagnostic criteria have found that both first-generation migrants and their offspring are at higher risk of developing schizophrenia than native-born white inhabitants. 2). 1). Diagnostic issues did not explain these differences, an important consideration given that some authors have suggested that immigrants are particularly vulnerable to brief psychotic episodes that do not meet stringent criteria for schizophrenia.