Central Regulation of the Pituitary-Adrenal Complex by E. V. Naumenko

By E. V. Naumenko

This monograph provides an updated account of the unique result of the author's learn within the complicated box of the relevant regulate over relationships that have turn into proven during evolution among the hypothalamus and the pituitary gland. the writer has restricted the scope of this examine on logical grounds to the research of relevant chemically reactive buildings within the rules of the adrenal glands in the course of the middleman of the hypothalamo-hypophyseal process. during the author's ability and services within the research of the large and infrequently advanced literature he has effectively undertaken a differential method of the research of the concrete position of catecholamines, acetylcholine, and serotonin relating to the endocrine procedure. The immense variety of experimental investigations and result of scientific observations released within the previous couple of many years have printed the humoral neurosecretory elements of the hypothalamus as impor­ tant regulators of the princ ipal capabilities of the pituitary gland and, via it, of the cyclic job of the peripheral crew of endocrine glands. till lately the sector of the cascade of regulatory in­ fluences previous the hypothalamus used to be terra incognita. it's hence that Evgenii Vladimirovich Naumenko's monograph ac­ quires its distinctive significance for the neurophysiologist, for its writer has striven, via experimental tools, to examine intimately the character of affects which for a very long time have been in­ terpreted because the normal dogmas of an summary "nervism.

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Example text

After stimulation ofthe hippocampus, adrenocortical function is altered in man also. , 1966). In the analysis of the results obtained after electrical stimulation of the anatomical structures of the brain, allowance must always be made for the parameters of the current used, for the response of the pituitary-adrenal system is particularly dependent on them. For example, stimulation of the dorsal part of the hippocampus by electric pulses with a frequency of 12-36/sec causes inhibition of secretion of adrenocortical hormones in response to nociceptive stimulation.

It is thus firmly established that many of the levels of the central nervous system from the hypothalamus to the cerebral cortex are concerned with the control of activity of the hypothalamohypophyseo-adrenal system. Although it is difficult at present to draw up a general scheme for the operation of the complete brain mechanism, it is evident that wherever the impulses arise they must eventually reach the hypophyseal zone of the hypothalamus, which secretes corticotrophin-releasing factor. The identity of the mediators transmitting the effect of nervous stimuli arising in the brain in response to the action of stressors of extremely diverse origin is a question to which the answer must be found.

Presumably in these animals the amygdalar complex contains chiefly elements which inhibit the function of the pituitary-adrenal system. Meanwhile, in rats amygdalectomy is not followed by an increase in the function of the pituitary-adrenal system, but against the background of stress induced by immobilization of these animals, the increase in the blood corticosterone level is delayed (Knigge, 1961). In chronic experiments on rats after bilateral electrolytic destruction of the amygdalar complex, the adrenal glands at first increase in size up to a maximum on the 13th day after the operation, after which they decrease in weight (Yamada and Greer, 1960).

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