By Errol C Friedberg
With a Foreword by means of Sydney Brenner (Nobel laureate in body structure or medication, 2002)
This biography info the lifetime of Paul Berg (Emeritus Professor at Stanford University), tracing Berg's existence from beginning, in 1926, to the current, with specified emphasis on his huge, immense clinical contributions, together with being the 1st to strengthen know-how that resulted in gene cloning technology. In 1980, Berg acquired a Nobel Prize in chemistry for this work.
as well as his contributions within the learn laboratory, Berg orchestrated and oversaw a ancient assembly at Asilomar, California that founded on a threatening controversy surrounding the belief by means of the various damaging capability of recombinant DNA know-how. This assembly did a lot to stop this controversy and to install position the legislation of recombinant DNA paintings, therefore placing fears to rest.
The recombinant DNA controversy was once a old end result of the invention of gene cloning. significantly, it represented a paramount instance of medical foresight and due diligence by way of the clinical neighborhood, instead of via regulatory entities within the usa and lots of different nations. the last word attractiveness of gene/DNA cloning ended in a brand new period of contemporary biology that flourishes to the present.
This e-book is aimed basically at scientists and people in education. The ebook strives to easily supply details for the final reader, yet isn't in particular adapted for a basic interpreting audience.
whereas many books conceal the recombinant DNA controversy, none have satisfactorily addressed this historical interval and are usually contradictory in regards to the many who is, where's, and why's concerned. also, the nice majority of those have been written via non-scientists. This biography of Paul Berg offers entry to various archived letters and files at Stanford college no longer formerly addressed, and to the chronology of occasions as recalled and documented via him, in addition to different key personalities, lots of whom have been interviewed.
Readership: Researchers, graduate scholars, undergraduates in existence sciences, drugs and chemistry and lay public.
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Extra resources for A Biography of Paul Berg : The Recombinant DNA Controversy Revisited
However, this book makes no attempt to systematically cover events that transpired elsewhere. In a nutshell, it is an account of an absorbing central controversy surrounding the emergence of this technology, and the players who were central to the hullabaloo from the late 1960’s to the mid-1970’s. indd xxix 23-05-2014 12:04:11 b1674 The Recombinant DNA Controversy Revisited b1674_FM xxx A Biography of Paul Berg left to others. Recombinant DNA technology heralded the feasibility of sequencing the entire human genome, comprising billions of nucleotides.
Notwithstanding her lack of formal training, Wolfe was an adept practitioner of the Socratic mode of teaching. When asked a question she would often respond with one of her own, designed to steer the enquiring student in a constructive direction when searching for answers. And if she thought that a question could be usefully addressed by conducting a modest laboratory experiment, she would go so far as to suggest one. 19 Abraham Lincoln High ultimately named one of the main school building wings after Sophie Wolfe.
He wrote: For the past fifteen years or so, my research has been concerned primarily with the biochemistry of genetic processes and more specifically with the enzymatic mechanisms of replication, transcription and translation in microbial systems. This approach has uncovered much important information; but, equally important, now we can begin to examine and interpret more complex biologic questions in terms of the concepts developed with the microbial models. How is the expression of genetic information regulated by intrinsic and extrinsic factors in eukaryotic cells?